The reason why exercise has this impact is unknown, but the researchers speculate that it may be because it lowers insulin levels, increases DNA and antioxidant repair pathways, and increases autophagy-the body’s natural process of eliminating damaged and old cells. He explains, “This is adding to that saying that high-intensity exercise over the course of your life will contribute to the benefits of ageing in a healthy form,” noting that beginning at any time in life will still prevent the buildup of these cells from progressing. The results are positive, but he would like to see a larger sample size. He points out that although the researchers only examined one indicator of cell senescence, it was biassed in favour of males. “One conceivable anti-aging method is to target the key signs of ageing,” says Keefe Chan, a senior researcher at the Peter MacCallum Cancer Institute who studies cell senescence: “the concept of high-intensity endurance activities in humans So, for the first time, we demonstrate that endurance exercise prevents the formation of senescent cells that secrete pro-inflammatory cytokines and cancer-promoting chemicals at the molecular level. In fact, the levels of cell senescence indicators in the runners in their 50s and 60s were comparable to those in their 20s.įontana, who is currently the Scientific Director of the Charles Perkins Centre RPA Clinic at the University of Sydney, claims that this study demonstrates that exercise has additional, more molecular effects in addition to the usual powerful metabolic effects, such as improved insulin sensitivity, glucose metabolism, blood pressure, lipid profile, and BDNF. They discovered that markers of cell senescence were much higher in the middle-aged males than in the young inactive men. Nevertheless, this growth was “substantially reduced” in the middle-aged, age-matched endurance runners.
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